The Ultimate Guide To mif

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The crystal buildings with the MIF-inhibitor complexes were being utilised because the First templates for virtual screening. The Protein Preparation Wizard module in Schrödinger was utilised to prepare Each and every MIF advanced. The ligand located inside the Energetic internet site between chains A and B was preserved. The advanced was then refined Along with the OPLS drive industry [26]. Pro1, an important nucleophilic residue, was protonated according to experimental and theoretical success [27].

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